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- Title
Influência da administração tardia do surfactante exógeno na evolução clínica de recém-nascidos muito pré-termo.
- Authors
Furtado de Mendonça, Patricia Queiroz; Araújo Vieira, Alan; Costa Bueno, Arnaldo; Andrade Lopes, José Maria
- Abstract
Objective: to assess whether the timing of surfactant administration influences the clinical evolution of very preterm infants. Methods: observational study using data prospectively collected from very preterm infants and their mothers, divided into two groups: group 1 = 28 weeks to 29 weeks and 6 days, group 2 = 30 weeks to 31 weeks and 6 days. Each group was divided in early surfactant administration (until two hours of life) and late surfactant administration (more than two hours of life) and then, compared in terms of perinatal characteristics, the presence of morbidities and mortality. Continuous variables were compared using the Student's t test or non-parametric test; categorical variables were compared using the chi-square test. Logistic regression was used to assess the association between the significant variables. The statistical package SPSS 16.0 was used and a value of p<0.05 was considered significant. This study was approved by the research ethics committee. Results: six hundred preterm infants were evaluated in group 1 and 503 in group 2. Early surfactant administration in group 1 was more frequently in lower weight and gestational age preterm at birth and was associated to severe peri and intraventricular hemorrhage; in the two groups, the need for orotracheal intubation in the delivery room increased the chance of early administration of exogenous surfactant. Morbidity and mortality were not different between the groups. Conclusions: the timing of surfactant administration did not influence clinical evolution and neonatal mortality in very preterm infants.
- Publication
Revista da Faculdade de Ciências Médicas de Sorocaba, 2021, Vol 23, Issue 2, p34
- ISSN
1517-8242
- Publication type
Article
- DOI
10.23925/1984-4840.2021v23i2a2