We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyalangium ruber sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites.
- Authors
Yi Zang; Xianjiao Zhang; Zhe Wang; Qingyi Tong; Yang Zhou; Qing Yao; Honghui Zhu
- Abstract
Myxobacteria are special bacteria with wide adaptability, which are rich sources of structurally diverse natural products with intriguing biological properties. Here, a gram-negative myxobacterium strain s54d21T was isolated from the sediment of a wetland park in China using the Escherichia coli baiting method. Based on 16S rRNA gene sequence and genomic data, the strain was demonstrated to be a novel species of a rare genus Hyalangium, designated Hyalangium ruber sp. nov (type strain s54d21T = GDMCC 1.1945T = JCM 39263T). The subsequent chemical investigation of the strain s54d21T led to the isolation of three rare 3,5,6-trisubstituted 2(1H)-pyrazinones, namely, hyalanones A-C (1-3), together with a known macrolactin A (4). Those new structures and their absolute configurations were unambiguously assigned by extensive analyses of spectroscopic data and density functional theory (DFT) calculations. In biological assays, compound 4 exhibited moderate cytotoxic activities against human cell lines RKO, A549, and NCM460 with IC50 values ranging from 27.21 to 32.14 µM.
- Subjects
CHINA; METABOLITES; BIOLOGICAL assay; GRAM-negative bacteria; DENSITY functional theory; MYXOBACTERALES
- Publication
Frontiers in Microbiology, 2024, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2024.1369499