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- Title
The Gut Microbe-Derived Metabolite Trimethylamine N-Oxide in Patients With Systemic Lupus Erythematosus.
- Authors
Salah, Mohamed; Shemies, Rasha Samir; Elsherbeny, Mona; Faisal, Sarah; Enein, Asmaa
- Abstract
The article explores the association between the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) and systemic lupus erythematosus (SLE). The study found that TMAO levels were higher in healthy controls compared to SLE patients, suggesting that dietary patterns and ingested drugs may confound the utility of TMAO as a potential marker in different diseases. The study also examined the clinical and demographic criteria of SLE patients with and without nephritis, finding no significant difference in most clinical manifestations between the two groups. However, patients with lupus nephritis had higher levels of urinary protein and anti dsDNA antibodies. The study also found a correlation between TMAO and anti-dsDNA titres. The article emphasizes the need for further research with larger sample sizes to fully understand the diagnostic and prognostic utility of TMAO in autoimmune diseases. The references cited in the article cover topics such as the activation of macrophages in lung injury, successful treatment with retinoids in lupus nephritis, and the association between gut microbiota and rheumatic diseases. The study was conducted in adherence to ethical principles for medical research involving human subjects.
- Subjects
SYSTEMIC lupus erythematosus; PATIENTS; REGULATORY T cells; SJOGREN'S syndrome; DISEASE risk factors; GUT microbiome; ENTEROTYPES; METABOLOMICS
- Publication
Scripta Medica, 2024, Vol 55, Issue 1, p43
- ISSN
0350-8218
- Publication type
Article
- DOI
10.5937/scriptamed55-45977