We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology.
- Authors
Kim, Taewon; Yi, Dahyun; Byun, Min Soo; Ahn, Hyejin; Jung, Joon Hyung; Kong, Nayeong; Kim, Min Jung; Jung, Gijung; Lee, Jun-Young; Lee, Yun-Sang; Kim, Yu Kyeong; Lee, Dong Young
- Abstract
Background: Hypertension has been associated with Alzheimer's disease (AD) dementia as well as vascular dementia. However, the underlying neuropathological changes that link hypertension to AD remain poorly understood. In our study, we examined the relationships of a history of hypertension and high current blood pressure (BP) with in vivo AD pathologies including β-amyloid (Aβ) and tau and also investigated whether a history of hypertension and current BP respectively affect the association between Aβ and tau deposition. Methods: This cross-sectional study was conducted as part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease, a prospective cohort study. Cognitively normal older adults who underwent both Aβ and tau positron emission tomography (PET) (i.e., [11C]-Pittsburgh compound B and [18F] AV-1451 PET) were selected. History of hypertension and current BP were evaluated and cerebral Aβ and tau deposition measured by PET were used as main outcomes. Generalized linear regression models were used to estimate associations. Results: A total of 68 cognitively normal older adults (mean [SD] age, 71.5 [7.4] years; 40 women [59%]) were included in the study. Neither a history of hypertension nor the current BP exhibited a direct association with Aβ or tau deposition. However, the synergistic interaction effects of high current systolic (β, 0.359; SE, 0.141; p = 0.014) and diastolic (β, 0.696; SE, 0.158; p < 0.001) BP state with Aβ deposition on tau deposition were significant, whereas there was no such effect for a history of hypertension (β, 0.186; SE, 0.152; p = 0.224). Conclusions: The findings suggest that high current BP, but not a history of hypertension, synergistically modulate the relationship between cerebral Aβ and tau deposition in late-life. In terms of AD prevention, the results support the importance of strict BP control in cognitively normal older adults with hypertension.
- Subjects
PITTSBURGH (Pa.); HYPERTENSION; TAU proteins; POSITRON emission tomography; ALZHEIMER'S disease; VASCULAR dementia
- Publication
Alzheimer's Research & Therapy, 2022, Vol 14, Issue 1, p1
- ISSN
1758-9193
- Publication type
Article
- DOI
10.1186/s13195-022-01149-7