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- Title
Effect of the Organic Functionality on the Synthesis and Antimicrobial Activity of Silver Nanoparticles.
- Authors
Pandey, P. C.; Tiwari, Atul Kumar; Gupta, Munesh Kumar; Pandey, Govind; Narayan, Roger J
- Abstract
In this paper, the effects of the organic reducing agent and 3-aminopropyltrimethoxysilane on the synthesis and properties of mono-, bi-, and trimetallic noble metal nanoparticles were considered; the antimicrobial activity of these nanomaterials was also evaluated. It was shown that 3-aminoptopyltrimethoxysilane-treated noble metal cations undergo rapid conversion into nanoparticles in the presence of three organic reducing agents, namely, 3-glycidoxypropyltrimethoxysilane (3-GPTMS), cyclohexanone and formaldehyde; the nanoparticles were formed on the order of one minute under microwave incubation. Bimetallic nanoparticles were formed by simultaneous or sequential reduction of metal cations; the formation of trimetallic nanoparticles containing gold, silver and palladium was demonstrated using a similar approach. The nanoparticles were characterized using UV-Visible light spectrophotometry, transmission electron microscopy and zeta potential measurements. All three nanoparticles exhibited a size ≤ 10 nm size. The nanoparticles showed antimicrobial activity against Acinetobacter baumannii. Scanning electron microscopy imaging showed an alteration in the size and shape of nanoparticle-treated bacterium, with bleb formation and cell wall disruption observed within 1 h of incubation at the MBC values of the nanoparticles. Fluorescence spectrophotometric imaging of silver nanoparticle-Acinetobacter baumannii interactions suggested selective binding of silver nanoparticles to surface proteins. Our results showed the preparation of the novel silver nanoparticles with potent Anti-Acinetobacter baumannii activity, which can serve as an alternative to conventional antimicrobial agents.
- Subjects
SILVER nanoparticles; PRECIOUS metals; ORGANIC synthesis; METAL nanoparticles; NANOPARTICLES; GOLD nanoparticles; TRANSMISSION electron microscopy
- Publication
Nano Life, 2020, Vol 10, Issue 3, pN.PAG
- ISSN
1793-9844
- Publication type
Article
- DOI
10.1142/S1793984420500026