We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Subcutaneous Biologics: Clinical Pharmacology and Drug Development.
- Authors
Ait‐Oudhia, Sihem; Chen, Joseph; Li, Junyi; van der Graaf, Piet H.
- Abstract
This article explores the development and administration of subcutaneous biologics, which are drugs derived from living organisms. It discusses the history of biologics and how genetic engineering has allowed for the modification of these drugs. The article focuses on the advantages of subcutaneous administration, such as convenience and cost-effectiveness, and discusses the challenges involved in developing subcutaneous formulations and delivery devices. It includes case studies and reviews that explore different aspects of subcutaneous biologics. The goal of the article is to optimize the clinical advancement of subcutaneous biologics and improve patient access to these therapies. The article also emphasizes the importance of studying the subcutaneous route of administration for biologic drugs and presents case studies that demonstrate the use of modeling and simulation techniques to optimize dosing strategies. The authors highlight the potential of subcutaneous delivery to improve patient care and treatment outcomes. They conclude that further research and development in this area can lead to enhanced healthcare effectiveness.
- Subjects
CLINICAL pharmacology; DRUG development; BIOLOGICALS; THROMBOPOIETIN receptors; ERYTHROPOIETIN receptors; MEDICAL personnel; T cells; MONOCLONAL antibodies; PURE red cell aplasia
- Publication
Clinical Pharmacology & Therapeutics, 2024, Vol 115, Issue 3, p385
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.3179