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- Title
The INK4a/ARF locus and melanoma.
- Authors
Sharpless, E; Chin, Lynda
- Abstract
Inactivation of the INK4a/ARF (or CDKN2a) locus is a common and critical genetic event in the development of human and mouse melanoma. This locus engages the Rb and p53 tumor suppressor pathways through its capacity to encode two distinct gene products, p16INK4a and p14ARF. This review highlights the body of evidence supporting a role for both p16INK4a and p14ARF in the suppression of melanoma, and speculates as to why this locus is preferentially targeted in this tumor type. In addition, the potential importance of these two pathways in mediating UV-induced melanoma genesis will be addressed via genetic and molecular evidence in the mouse.Oncogene (2003) 22, 3092-3098. doi:10.1038/sj.onc.1206461
- Subjects
TUMORS; MELANOMA; TUMOR suppressor proteins; MICE; PRECANCEROUS conditions
- Publication
Oncogene, 2003, Vol 22, Issue 20, p3092
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1206461