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- Title
Integrity of the Anterior Visual Pathway and Its Association with Ambulatory Performance in Multiple Sclerosis.
- Authors
Balantrapu, Swathi; Sandroff, Brian M.; Pula, John H.; Motl, Robert W.
- Abstract
Background. Retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV) represent markers of neuroaxonal degeneration within the anterior visual pathway that might correlatewith ambulation in persons withmultiple sclerosis (MS).Objective. This study examined the associations between RNFLT and TMV with ambulatory parameters in MS. Methods. Fifty-eightMS patients underwent a neurological examination for generation of an expanded disability status scale (EDSS) score and measurement of RNFLT and TMVusing optical coherence tomography (OCT). Participants completed the 6-minute walk (6MW) and the timed 25-foot walk (T25FW).The associations were examined using generalized estimating equation models that accounted for withinpatient, inter-eye correlations, and controlled for disease duration, EDSS score, and age. Results. RNFLT was not significantly associated with 6MW (P = 0.99) or T25FW (P = 0.57). TMV was significantly associated with 6MW (P = 0.023) and T25FW (P = 0.005).Thecoefficients indicated that unit differences in6MW(100 feet) and T25FW(1 second)were associatedwith 0.040 and -0.048 unit differences in TMV (mm3), respectively. Conclusion. Integrity of the anterior visual pathway, particularly TMV, might represent a noninvasive measure of neuroaxonal degeneration that is correlated with ambulatory function in MS.
- Subjects
MULTIPLE sclerosis; OUTPATIENT medical care; NEURODEGENERATION; BIOMARKERS; OPTICAL coherence tomography; DISEASE duration
- Publication
Multiple Sclerosis International, 2013, p1
- ISSN
2090-2654
- Publication type
Article
- DOI
10.1155/2013/481035