We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Consumption of High-Polyphenol Dark Chocolate Improves Endothelial Function in Individuals with Stage 1 Hypertension and Excess Body Weight.
- Authors
de Paula Nogueira, Lívia; Paranhos Knibel, Marcela; Gonçalves Torres, Márcia Regina Simas; Nogueira Neto, José Firmino; Felipe Sanjuliani, Antonio
- Abstract
Background. Hypertension and excess body weight are important risk factors for endothelial dysfunction. Recent evidence suggests that high-polyphenol dark chocolate improves endothelial function and lowers blood pressure. This study aimed to evaluate the association of chocolate 70% cocoa intake with metabolic profile, oxidative stress, inflammation, blood pressure, and endothelial function in stage 1 hypertensives with excess body weight. Methods. Intervention clinical trial includes 22 stage 1 hypertensives without previous antihypertensive treatment, aged 18 to 60 years and presents a body mass index between 25.0 and 34.9 kg/m2. All participants were instructed to consume 50 g of chocolate 70% cocoa/day (2135 mg polyphenols) for 4 weeks. Endothelial function was evaluated by peripheral artery tonometry using Endo-PAT 2000 (Itamar Medical). Results. Twenty participants (10 men) completed the study. Comparison of pre-post intervention revealed that (1) there were no significant changes in anthropometric parameters, percentage body fat, glucose metabolism, lipid profile, biomarkers of inflammation, adhesion molecules, oxidized LDL, and blood pressure; (2) the assessment of endothelial function through the reactive hyperemia index showed a significant increase: 1.94 ± 0.18 to 2.22 ± 0.08, P = 0.01. Conclusion.In individuals with stage 1 hypertension and excess body weight, highpolyphenol dark chocolate improves endothelial function.
- Subjects
CARDIOVASCULAR disease diagnosis; CACAO; ACADEMIC medical centers; BEHAVIOR modification; BLOOD pressure measurement; BODY weight; DIET; ENDOTHELIUM; HEALTH behavior; HOMEOSTASIS; HYPERTENSION; LIPOPROTEINS; NUTRITION; PHENOLS; PLASTIC surgery; DATA analysis; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
International Journal of Hypertension, 2012, p1
- ISSN
2090-0384
- Publication type
Article
- DOI
10.1155/2012/147321