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- Title
Tight-Binding Modeling of Nucleic Acid Sequences: Interplay between Various Types of Order or Disorder and Charge Transport.
- Authors
Lambropoulos, Konstantinos; Simserides, Constantinos
- Abstract
This review is devoted to tight-binding (TB) modeling of nucleic acid sequences like DNA and RNA. It addresses how various types of order (periodic, quasiperiodic, fractal) or disorder (diagonal, non-diagonal, random, methylation et cetera) affect charge transport. We include an introduction to TB and a discussion of its various submodels [wire, ladder, extended ladder, fishbone (wire), fishbone ladder] and of the process of renormalization. We proceed to a discussion of aperiodicity, quasicrystals and the mathematics of aperiodic substitutional sequences: primitive substitutions, Perron–Frobenius eigenvalue, induced substitutions, and Pisot property. We discuss the energy structure of nucleic acid wires, the coupling to the leads, the transmission coefficients and the current–voltage curves. We also summarize efforts aiming to examine the potentiality to utilize the charge transport characteristics of nucleic acids as a tool to probe several diseases or disorders.
- Subjects
NUCLEIC acid probes; CURRENT-voltage curves; NUCLEOTIDE sequence; APERIODICITY
- Publication
Symmetry (20738994), 2019, Vol 11, Issue 8, p968
- ISSN
2073-8994
- Publication type
Article
- DOI
10.3390/sym11080968