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- Title
Vitamin D Status and Reference Intervals Measured by Liquid Chromatography–Tandem Mass Spectrometry for the Early Adulthood to Geriatric Ages in a South Korean Population during 2017–2022.
- Authors
Park, Jooheon; Choi, Yongjun; Cho, Seon; Park, Hyeran; Kim, Suyoung; Cho, Han-Ik; Nah, Eun-Hee
- Abstract
This study aimed to describe the latest 25-hydroxyvitamin D (25(OH)D) status of the South Korean population aged ≥ 20 years using 25(OH)D concentrations measured by liquid chromatography–tandem mass spectrometry and to determine the factors associated with total 25(OH)D concentrations. This cross-sectional, retrospective study consecutively selected 119,335 subjects with a median age of 57 (20–101) years who underwent health checkups among 13 Korean cities during 2017–2022. The total 25(OH)D concentration was 54.5 ± 24.0 nmol/L (mean ± SD). The 7.6%, 47.5%, and 82.9% of participants had 25(OH)D less than 25, 50, and 75 nmol/L, respectively. The prevalence of 25(OH)D deficiency (<25 nmol/L) was higher in females than in males (8.9% vs. 6.1%) and varied between age groups, decreasing in older subjects. Those aged 20–29 years had the highest prevalence of 25(OH)D deficiency (23.0% in females and 20.1% in males), which also varied between cities. In the adjusted model, female sex, older age, summer and autumn seasons, lower body mass index (<25 kg/m2), and lower high-sensitivity C-reactive protein concentration (<1 mg/L) were associated with higher total 25(OH)D concentrations. This study could provide an exact understanding of the status of vitamin D and help devise strategies to prevent vitamin D deficiency among the Korean population.
- Subjects
SOUTH Korea; REFERENCE values; VITAMIN D deficiency; RISK assessment; CROSS-sectional method; STATISTICAL models; LIQUID chromatography-mass spectrometry; DATA analysis; SEASONS; BODY mass index; POPULATION health; MULTIPLE regression analysis; SEX distribution; RETROSPECTIVE studies; DISEASE prevalence; DESCRIPTIVE statistics; CHI-squared test; AGE distribution; SERUM; VENOUS puncture; MASS spectrometry; MEDICAL records; ACQUISITION of data; ONE-way analysis of variance; STATISTICS; DATA analysis software; VITAMIN D; C-reactive protein; OBESITY; DISEASE risk factors; ADULTS; MIDDLE age; OLD age
- Publication
Nutrients, 2024, Vol 16, Issue 5, p604
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16050604