We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High Extra Virgin Olive Oil Consumption Is Linked to a Lower Prevalence of NAFLD with a Prominent Effect in Obese Subjects: Results from the MICOL Study.
- Authors
Tedesco, Calogero Claudio.; Bonfiglio, Caterina; Notarnicola, Maria; Rendina, Maria; Castellaneta, Antonino; Di Leo, Alfredo; Giannelli, Gianluigi; Fontana, Luigi
- Abstract
Extra virgin olive oil (EVOO) has healthy benefits for noncommunicable diseases (NCDs). However, limited evidence is available about the effects of liver disease and non-alcoholic fatty liver disease (NAFLD). We evaluate whether dose-increased consumption of EVOO is associated with a lower prevalence of NAFLD and if these effects vary based on body weight. The study included 2436 subjects with a 33% NAFLD prevalence. Daily EVOO was categorized into tertiles: low (0–24 g/day), moderate (25–37 g/day), and high consumption (>37 g/day). Subjects were also classified by body mass index (BMI) as normo-weight (18.5–24.9), overweight (25–29.9), and obese (≥30). Logistic regression analysis was applied to calculate odds ratios (ORs) for NAFLD, considering a 20-gram increment in EVOO intake and accounting for EVOO categories combined with BMI classes. The ORs were 0.83 (0.74;0.93) C.I. p = 0.0018 for continuous EVOO, 0.89 (0.69;1.15) C.I. p = 0.37, and 0.73 (0.55;0.97) C.I. p = 0.03 for moderate and high consumption, respectively, when compared to low consumption. Overall, the percent relative risk reductions (RRR) for NAFLD from low to high EVOO consumption were 18% (16.4%;19.2%) C.I. and 26% (25%;27.4%) C.I. in overweight and obese subjects. High EVOO consumption is associated with a reduced risk of NAFLD. This effect is amplified in overweight subjects and even more in obese subjects.
- Subjects
FATTY liver prevention; THERAPEUTIC use of olive oil; OBESITY; OLIVE oil; MEDITERRANEAN diet; RELATIVE medical risk; BODY weight; CONFIDENCE intervals; FOOD consumption; FATTY liver; NON-alcoholic fatty liver disease; LIVER diseases; RESEARCH funding; DESCRIPTIVE statistics; ODDS ratio; LOGISTIC regression analysis; DATA analysis software; DIETARY fats; DOSE-response relationship in biochemistry
- Publication
Nutrients, 2023, Vol 15, Issue 21, p4673
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15214673