We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation.
- Authors
Dus-Zuchowska, Monika; Walkowiak, Jaroslaw; Morawska, Anna; Krzyzanowska-Jankowska, Patrycja; Miskiewicz-Chotnicka, Anna; Przyslawski, Juliusz; Lisowska, Aleksandra
- Abstract
Background: Atherosclerosis (AT) is a chronic inflammatory process in which oxidative stress is the key event. Amaranth oil (AmO) has potential hypolipidemic and antiatherogenic effects. The aim of the study was to compare the effects of AmO and rapeseed oil (RaO) supplementation on expression of early markers of AT and lipid profile in obese or overweight subjects. Methods: A randomized, double-blinded cross-over study was conducted, in which participants took 20 mL of AmO in the first arm and 20 mL RaO in the second arm, switching after the washout period. Serum concentrations of adhesion molecules (sP-selectin, sVCAM-1), high-sensitivity C-reactive protein (hsCRP), asymmetric dimethylarginine (ADMA), and lipid profile were assessed before and after nutritional interventions. In addition, anthropometric parameters were measured. Results: The total (TC) and low-density lipoprotein (LDL) cholesterol concentrations increased significantly in the AmO group in comparison with RaO (ΔTC 5.52 ± 35 vs. −8.43 ± 17.65 mg/dL; p = 0.002 and 4.43 ± 34.96 vs. −7.55 ± 16.41 mg/dL; p = 0.002, respectively). There were no significant differences in other parameters analyzed between the groups. Conclusion: The use of AmO instead of RaO may increase cardiovascular risk in obese and overweight subjects.
- Subjects
LIPID metabolism; LIPID analysis; OBESITY complications; ANALYSIS of triglycerides; ANTHROPOMETRY; ATHEROSCLEROSIS; BIOMARKERS; C-reactive protein; CANOLA oil; CARDIOVASCULAR diseases risk factors; LOW density lipoproteins; RESEARCH funding; STATISTICAL sampling; VEGETABLE oils; PLANT extracts; RANDOMIZED controlled trials; BLIND experiment; EVALUATION
- Publication
Nutrients, 2019, Vol 11, Issue 12, p3069
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11123069