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- Title
Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice.
- Authors
Kim, Na-Hyun; Jegal, Jonghwan; Kim, Yun Na; Heo, Jeong-Doo; Rho, Jung-Rae; Yang, Min Hye; Jeong, Eun Ju
- Abstract
Berries of Aronia melanocarpa (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from A. melanocarpa methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer binding protein α), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid–binding protein). A. melanocarpa extract-treated (100 or 200 mg/kg/day on body weight) high fat diet (HFD)-induced obese mice showed significant decreases in body weight, serum triglyceride (TG), and low-density lipoprotein cholesterol (LDLC) levels and improved insulin sensitivity as compared with HFD controls. This research shows A. melanocarpa extract is potentially beneficial for the suppression of HFD-induced obesity.
- Subjects
BODY weight; CARRIER proteins; CELL physiology; FAT cells; FAT content of food; FRUIT juices; GENE expression; GLYCOSIDES; INSULIN resistance; LOW density lipoproteins; OBESITY; POLYPHENOLS; TRANSCRIPTION factors; TRANSFERASES; TRIGLYCERIDES; PHYTOCHEMICALS; PLANT extracts; PEROXISOME proliferator-activated receptors
- Publication
Nutrients, 2018, Vol 10, Issue 11, p1734
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10111734