We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High Fat Mixed Meal Tolerance Test Leads to Suppression of Osteocalcin Decrease in Obese Insulin Resistant Subjects Compared to Healthy Adults.
- Authors
Razny, Urszula; Goralska, Joanna; Zdzienicka, Anna; Gruca, Anna; Zapala, Barbara; Micek, Agnieszka; Dembinska-Kiec, Aldona; Solnica, Bogdan; Malczewska-Malec, Malgorzata
- Abstract
Nutrients influence bone turnover. Carboxylated osteocalcin (Gla-OC) participates in bone formation whereas its undercarboxylated form (Glu-OC) acts as a hormone in glucose metabolism. The aim of the study was to determine the responses of Gla-OC, Glu-OC, and total-OC (calculated as the sum of Gla-OC and Glu-OC) to a high fat mixed meal tolerance test (HFMTT) in non-obese (body mass index (BMI) < 30 kg/m2, n = 24) and obese subjects (30 < BMI < 40 kg/m2, n = 70) (both sexes, aged 25–65 years). Serum Gla-OC and Glu-OC were measured at baseline as well as at 2 and 6 h during a HFMTT by enzyme-linked immunosorbent assay (ELISA). Baseline Gla-OC, Glu-OC, and total-OC levels were lower in obese individuals compared to non-obese participants (p = 0.037, p = 0.016 and p = 0.005, respectively). The decrease in Gla-OC and total-OC, but not in Glu-OC, concentrations during the HFMTT was suppressed in obese, but not in non-obese controls (p < 0.05, p < 0.01, p = 0.08, respectively). Subjects with the highest homeostatic model assessment for insulin resistance (HOMA-IR) index values had a less pronounced decrease in total-OC compared to patients with values of HOMA-IR index in the 1st quartile (p < 0.05). Net incremental area under Gla-OC inversely correlated with adiponectin (rho = −0.35, p = 0.001). Increase in insulin sensitivity and adiponectin level in obese subjects could beneficially influence postprandial bone turnover expressed by osteocalcin concentration.
- Subjects
BONE remodeling; ENZYME-linked immunosorbent assay; FAT content of food; HOMEOSTASIS; INGESTION; INSULIN resistance; OBESITY; BODY mass index; ADIPONECTIN; OSTEOCALCIN
- Publication
Nutrients, 2018, Vol 10, Issue 11, p1611
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10111611