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- Title
Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome.
- Authors
Lee, Young Ho; Yang, Hyun; Lee, Sang R.; Kwon, Sun Woo; Hong, Eui-Ju; Lee, Hye Won
- Abstract
Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-known in Asian countries for its usage in food ingredients and traditional medicines. It is also studied for its many effects. These include activation of immune responses, antihypertensive effects, and antioxidant effects. Using letrozole-induced PCOS rats, we focused on herbal therapy using extract of Allium fistulosum (AF; A. fistulosum) roots to improve ovarian functions. As a nonsteroidal aromatase inhibitor, letrozole blocks conversion of testosterone to estrogen and subsequently induces PCOS phenomenon. We divided six-week-old female rats into four groups, including control, letrozole, letrozole + AF extract, and temporary letrozole groups. In our study, treatment with AF extract shows a low plasma LH/FSH ratio, and reveals high estrogen levels, ovarian morphology, folliculogenesis-related genes, and aromatase expression under PCOS mimic conditions. We concluded that AF extract administration influenced aromatase production, enhanced the estrogen steroid synthesis, and consequently restored the estrogenic feedback mechanism on the pituitary-ovary system.
- Subjects
ANTIOXIDANTS; ASIANS; ESTROGEN; FOLLICLE-stimulating hormone; HERBAL medicine; ANTIHYPERTENSIVE agents; LUTEINIZING hormone; ONIONS; OVARIES; PLANT roots; POLYCYSTIC ovary syndrome; TESTOSTERONE; AROMATASE inhibitors; PREVENTION
- Publication
Nutrients, 2018, Vol 10, Issue 10, p1430
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10101430