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- Title
DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.
- Authors
Zhivagui, Maria; Hoda, Areebah; Valenzuela, Noelia; Yeh, Yi-Yu; Dai, Jason; He, Yudou; Nandi, Shuvro P.; Otlu, Burcak; Van Houten, Bennett; Alexandrov, Ludmil B.
- Abstract
Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction. Analysis of somatic mutations reveals a dose-dependent increase of C:G>A:T substitutions in irradiated samples with mutagenic patterns similar to mutational signatures previously attributed to reactive oxygen species. In summary, this study demonstrates that radiation emitted by UV-nail polish dryers can both damage DNA and permanently engrave mutations on the genomes of primary mouse embryonic fibroblasts, human foreskin fibroblasts, and human epidermal keratinocytes. Nail polish dryers commonly emit ultraviolet A (UVA) light, but the effects of this irradiation on mammalian cells remain unclear. Here, the authors examine the effects of UVA irradiation by a nail polish dryer on the genomes of mammalian cell lines, finding high levels of reactive oxygen species and related mutational signatures.
- Subjects
SOMATIC mutation; NAIL polish; DNA damage; IRRADIATION; REACTIVE oxygen species; KERATINOCYTE differentiation; SKIN cancer
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-35876-8