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- Title
In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.".
- Authors
Plá, Virginia; Bitsika, Styliani; Giannetto, Michael J.; Ladron-de-Guevara, Antonio; Gahn-Martinez, Daniel; Mori, Yuki; Nedergaard, Maiken; Møllgård, Kjeld
- Abstract
This document is a response to a comment made by Dr. Neuhuber regarding a previous study on the structural characterization of meningeal membranes. The authors address the comment by explaining that the fixation process used in the study causes shrinkage of the brain, which distorts the meningeal membranes. They provide measurements confirming that the fixative used has a higher osmolality than physiological levels. The authors also emphasize that previous descriptions of meningeal layers are based on fixed tissue, which may introduce artifacts. They further discuss the role of a specific meningeal membrane called SLYM in creating perivascular spaces and ensuring unidirectional glymphatic transport. The authors conclude by stating that the structural and organizational characteristics of meningeal membranes may vary in different parts of the central nervous system.
- Subjects
SUBARACHNOID space; OUTER space; FLUIDS
- Publication
Fluids & Barriers of the CNS, 2024, Vol 21, Issue 1, p1
- ISSN
2045-8118
- Publication type
Article
- DOI
10.1186/s12987-024-00540-w