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- Title
Effect of Hypobaric Hypoxia, Simulating Conditions During Long-Haul Air Travel, on Coagulation, Fibrinolysis, Platelet Function, and Endothelial Activation.
- Authors
Toff, William D.; Jones, Chris I.; Ford, Isobel; Pearse, Robert J.; Watson, Henry G.; Watt, Stephen J.; Ross, John A. S.; Gradwell, David P.; Batchelor, Anthony J.; Abrams, Keith R.; Meijers, Joost C. M.; Goodall, Alison H.; Greaves, Michael
- Abstract
The article presents a medical study examining the association between hemostasis and hypobaric hypoxia, which may be experienced during long-haul air travel. According to the article, the results of the study do not support the theory that hypobaric hypoxia is connected to prothrombotic changes of the hemostatic system in people who have a low risk of venous thromboembolism. Participants with factor V Leiden G1691A and prothrombin G20210A mutation were excluded from the study. The article discusses changes in the hypobaric and normobaric exposures, platelet function, fibrinolysis, endothelial activation, and coagulation.
- Subjects
HYPOXEMIA; INFLUENCE of altitude; HEMOSTASIS; MEDICAL research; CLINICAL trials; AIR travel; AIR travelers; PHYSIOLOGICAL effects of atmospheric pressure; FIBRINOLYSIS; VENOUS thrombosis
- Publication
JAMA: Journal of the American Medical Association, 2006, Vol 295, Issue 19, p2251
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.295.19.2251