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- Title
THE FIRST CASE OF ONYCHOMYCOSIS DUE TO EXOPHIALA DERMATITIDIS IN IRAN.
- Authors
Najafzadeh, Mohammad Javad; Falahati, Mehraban; Farahyar, Shirin; Zaini, Farideh; Ghasemi, Zeinab; Rezaei-Matehkolaei, Ali; Dolatabadi, Somayeh; Keisari, Maryam Saradeghi; Meis, Jacques
- Abstract
We report a rare case of onychomycosis due to Exophiala (Wangiella) dermatitis in a 54-year-old Iranian female with a history of no immunodeficiency, without underlying disease presented in 2011 to Raze hospital in Tehran, Iran. The patient was mountaineer, she has blackish pigmentation in toenail and distal area of the nail was empty. Scrapings were collected deeply from hyperkeratotic distal areas. Examination of potassium hydroxide mounts from the samples revealed brown, septate, branching hyphae. The scrapings were cultured on malt extract agar at 25°C. The colonies were initially moist and gray, becoming black or dark-green with dull surface. The fungus was identified as E. dermatitis by its morphological characteristics and through DNA sequencing of the internal transcribed spacer region of rDNA. In vitro antifungal susceptibility has shown that itraconazole and posaconazole (0. 063μg/ml) had the highest and fluconazole (16μg/ml), caspofungin (2μg/ml) and micafungin (4μg/ml) the lowest activity against E. dermatitis. Onychomycosis was considered as a fungal nail infection mainly caused by dermatophytes, sometimes yeasts and rarely caused by nondermatophyte molds such as dematiaceous fungi. This is the first report of onychomycosis due to E. dermatitis in Iran.
- Subjects
TEHRAN (Iran); ONYCHOMYCOSIS; SKIN inflammation; HUMAN skin color; POTASSIUM hydroxide; IDENTIFICATION of fungi; RECOMBINANT DNA; NUCLEOTIDE sequence
- Publication
Jundishapur Journal of Microbiology, 2013, p53
- ISSN
2008-3645
- Publication type
Article