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- Title
Diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension associated with CHD.
- Authors
Hella, Eslam; El Amrousy, Doaa; El-Serogy, Hesham; Zoair, Amr
- Abstract
<bold>Objective: </bold>To evaluate the diagnostic and predictive values of plasma connective tissue growth factor in children with pulmonary hypertension (PH)-related CHD.<bold>Patients and Methods: </bold>Forty patients with PH-related CHD were enrolled as group I, and 40 patients with CHD and no PH served as group II. Forty healthy children of matched age and sex served as a control group. Echocardiographic examinations and plasma connective tissue growth factor levels were performed for all included children. Cardiac catheterisation was performed for children with CHD only.<bold>Results: </bold>Plasma connective tissue growth factor levels were significantly higher in children with PH-related CHD compared to CHD-only patients and to control group and this elevation went with the severity of PH. There was a significant positive correlation between connective tissue growth factor levels and mean pulmonary pressure, pulmonary vascular resistance, and right ventricular diameter. A significant negative correlation was noticed between connective tissue growth factor levels, oxygen saturation, and right ventricular diastolic function. The sensitivity of plasma connective tissue growth factor as a diagnostic biomarker for PH was 95%, and the specificity was 90% at a cut-off value ≥650 pg/mL. The predictive value of plasma connective tissue growth factor for adverse outcome had a sensitivity of 88% and a specificity of 83% at a cut-off value ≥1900 pg/mL.<bold>Conclusion: </bold>Connective tissue growth factor is a promising biomarker with good diagnostic and predictive values in children with PH-related CHD.
- Publication
Cardiology in the Young, 2020, Vol 30, Issue 4, p533
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S104795112000058X