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- Title
Pulmonary vasodilator therapy in the failing Fontan circulation: rationale and efficacy.
- Authors
Snarr, Brian S.; Paridon, Stephen M.; Rychik, Jack; Goldberg, David J.
- Abstract
The Fontan operation is the final step of palliation for patients with a functionally single ventricle. Since its introduction in the 1970s, the Fontan surgery has become part of a successful surgical strategy that has improved single ventricle mortality. In recent years, we have become more aware of the limitations and long-term consequences of the Fontan physiology. Pulmonary vascular resistance plays an important role in total cavopulmonary circulation, and has been identified as a potential therapeutic target to mitigate Fontan sequelae. In this review, we will discuss the results of different pulmonary vasodilator trials and the use of pulmonary vasodilators as a treatment strategy for Fontan patients.
- Subjects
PULMONARY heart disease; VASODILATORS; CARDIOVASCULAR agents; PEDIATRIC cardiology; LUNG disease treatment; THERAPEUTICS
- Publication
Cardiology in the Young, 2015, Vol 25, Issue 8, p1489
- ISSN
1047-9511
- Publication type
journal article
- DOI
10.1017/S1047951115002309