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- Title
Interleukin-2 −330 and 166 gene polymorphisms in relation to aggressive or chronic periodontitis and the presence of periodontopathic bacteria.
- Authors
Reichert, S.; Machulla, H. K. G.; Klapproth, J.; Zimmermann, U.; Reichert, Y.; Gläser, C.; Schaller, H‐G.; Schulz, S.
- Abstract
Background and Objective: As a pro-inflammatory cytokine, interleukin-2 mediates the activation, growth and differentiation of T and B lymphocytes and natural killer cells. Promoter polymorphisms of the interleukin-2 gene have been associated with altered interleukin-2 production or identified as prognostic markers for various infectious diseases. Therefore, the aim of this study was to evaluate two polymorphisms at positions −330 T/G and 166 G/T in patients with generalized chronic periodontitis ( n = 58) or generalized aggressive periodontitis ( n = 73) in comparison with periodontitis-free controls ( n = 69). Material and Methods: Both interleukin-2 polymorphisms were analyzed using the polymerase chain reaction with sequence-specific primers. Distributions of single alleles, genotypes and haplotypes were calculated using the chi-square test. Risk factor analyses were carried out by logistic regression with respect to established cofactors for periodontitis. The presence of subgingival bacteria in an individual were analyzed using a molecular biological method (the micro-Ident® test). Results: The interleukin-2 genotype −330 TG occurred less frequently in patients with chronic periodontitis (25.9% vs. 49.3%). Moreover, this genotype decreased the adjusted odds ratio for chronic periodontitis (odds ratio = 0.394), whereas the interleukin-2 genotype 166 TT and the haplotype combination interleukin-2 −330,166 TT : TT were associated with an increased adjusted odds ratio (odds ratio = 2.82 or 2.97). For the latter interleukin-2 combination, a positive association for the subgingival presence of Porphyromonas gingivalis (81.3% vs. 59.5%) and bacteria of the ‘red complex’ (78.1% vs. 56.0%) was shown. Conclusion: The interleukin-2 genotypes −330 TG and 166 TT, as well as the combination genotype interleukin-2 TT : TT, could be putative prognostic factors for chronic periodontitis.
- Subjects
INTERLEUKIN-2; PERIODONTITIS; CYTOKINES; KILLER cells; LYMPHOCYTES; GENETIC polymorphisms
- Publication
Journal of Periodontal Research, 2009, Vol 44, Issue 5, p628
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2008.01173.x