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- Title
Outcomes of therapy‐related acute lymphoblastic leukemia in adults after allogeneic stem cell transplantation.
- Authors
Vasudevan Nampoothiri, Ram; Law, Arjun Datt; Lam, Wilson; Chen, Carol; Al‐Shaibani, Zeyad; Loach, David; Michelis, Fotios V.; Kim, Dennis (Dong Hwan); Mattsson, Jonas; Kumar, Rajat; Lipton, Jeffrey Howard; Viswabandya, Auro
- Abstract
Introduction: Therapy‐related acute lymphoblastic leukemia (t‐ALL) is an increasingly recognized subset of therapy‐related acute leukemia. There are limited data on the role of allogeneic hematopoietic stem cell transplantation (HSCT) in t‐ALL. Recent reports suggest comparable outcomes of t‐ALL with de novo ALL after HSCT. Patients and Methods: We retrospectively reviewed all patients of t‐ALL who underwent HSCT at our center. Patients were analyzed for prior malignancy, therapy, time to diagnosis of t‐ALL, clinical, laboratory characteristics, transplant details, relapse‐free survival (RFS), and overall survival (OS). Results: Eighteen patients (M:F ratio 1:1; Median age 44 years) underwent HSCT for t‐ALL. Median latent period from primary malignancy to t‐ALL was 44.8 months. 11q23 rearrangement and t(9;22) were present in 33.3% and 22.2% patients, respectively. Stem cell donors were matched related, matched unrelated, and haploidentical in 27.8% (n = 5), 55.6% (n = 10), and 16.7% (n = 3) patients, respectively. Five patients died before D+ 100 (27.8%). Estimated 2‐year RFS and OS were 47.1% and 51.8%, respectively. We did not find any pretransplant and post‐transplant risk factors that were predictive of improved OS or RFS after multivariate analysis. Conclusions: Allogeneic HSCT outcomes in t‐ALL were comparable to HSCT outcomes in de novo ALL. Multicenter studies with more patients and longer follow‐up may provide factors affecting outcome and survival.
- Subjects
STEM cell transplantation; LYMPHOBLASTIC leukemia; ACUTE leukemia; HEMATOPOIETIC stem cell transplantation; STEM cell donors
- Publication
European Journal of Haematology, 2020, Vol 105, Issue 1, p24
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13403