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- Title
Obesity, body composition, and risk of renal cell cancer: a population-based case-control study.
- Authors
Asal, Nabih R.; Theis, Ryan P.; Dolwick Grieb, Suzanne M.; Burr, Deborah; Benardot, Dan; Siddiqui, Tariq
- Abstract
Aim of the study This study assesses the role of body composition on renal cell carcinoma (RCC) among 335 cases and 337 controls in Florida and Georgia, 2003-2006. Subjects and Methods Cases were selected from participating hospitals and the Florida Cancer Data Registry. Controls were selected from the population using random-digit dialing, frequency-matched to cases by age, sex, and race. Cases and controls were assessed for body mass index (BMI), body fat percentage, and body fat distribution. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. Results Among men, significant associations were observed between RCC and BMI > 40 (OR = 3.5; 95% CI: 1.2, 10.4), upper quartile waist-to-hip ratio (OR = 2.0; 95% CI: 1.0, 3.9), and upper quartile suprailiac skinfold thickness (OR = 2.1; 95% CI: 1.1, 3.9). Significant linear trends between RCC and body fat percentage were observed for men (p = 0.042) and women (p = 0.032). Among women, associations were stronger for upper quartile caloric intake (OR = 2.3; 95% CI: 1.2, 4.6) and upper quartile fat intake (OR = 2.7; 95% CI: 1.4, 5.2). Conclusion These findings confirm known associations between BMI and RCC and implicate the role of body fat percentage, central obesity, and diet in RCC etiology.
- Subjects
RENAL cell carcinoma; HUMAN body composition; BODY mass index; RENAL cancer; SKINFOLD thickness; EPIDEMIOLOGY; ETIOLOGY of diseases
- Publication
International Journal of Health Science, 2009, Vol 2, Issue 1, p167
- ISSN
1791-4299
- Publication type
Article