We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ARTICHOKE (CYNARA SCOLYMUS L.) EXTRACTS ARE SHOWING CONCENTRATION-DEPENDENT HORMETIC AND CYTOTOXIC EFFECTS ON BREAST CANCER CELL LINES.
- Authors
Vígh, Szabolcs; Zsvér-Vadas, Zsanett; Pribac, Ciprian; Moş, Liana; Cziáky2, Zoltán; Czapár, Mária; Mihali, Ciprian Valentin; Turcuş, Violeta; Máthé, Endre
- Abstract
Chemomapping of artichoke (Cynara scolymus L.) leaf extracts revealed novel bioactive compounds with putative anti-tumor effects, and therefore, we set to analyze the cytotoxic effects of aqueous and alcoholic extracts on T-47D and ZR-75-1 human breast cancer cell lines. A concentration dependent hormetic response was detected in the case of aqueous extract, while the alcoholic extract featured a pronounced cytotoxic effect as inferred by the MTT proliferation assays. Immunocytochemical analyses of treated cells were suggesting that the observed cytotoxicity could be associated with cellular senescence and/or apoptosis. Our experimental data are suggesting that the artichoke could be a good candidate for the complementary treatment of certain human cancers but further studies are needed to shed light on all aspects related to its hormetic dose response and cytotoxic effect not talking about the putative hepatoprotective effect in relation to cancer therapy efficiency.
- Subjects
ARTICHOKES; BIOACTIVE compounds; TUMOR treatment; IMMUNOCYTOCHEMISTRY; CELL-mediated cytotoxicity; CANCER treatment
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2016, Vol 26, Issue 4, p423
- ISSN
1584-2363
- Publication type
Article