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- Title
A brief review on current antifungal agents.
- Authors
J., Anbhule Sachin; Aanandhi, M. Vijey
- Abstract
Nowadays, most of fungal infections such as candidoses can range from superficial mucous membrane infection to lifethreatening systemic mycoses. Candida infections give significant clinical problem globally due to most rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients, and patients those are on chemotherapy. In addition to this, a sharp increase in the aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs for these problems are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, the rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this review topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery, i.e., proposed novel mechanisms, new drug targets, and pathways. Here, we are reporting some new antifungal molecules.
- Subjects
DRUG development; ANTIFUNGAL agents; CANDIDIASIS treatment; HOSTS (Biology); COMPLICATIONS from organ transplantation; TARGETED drug delivery
- Publication
Drug Invention Today, 2018, Vol 10, Issue 1, p76
- ISSN
0975-7619
- Publication type
Article