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- Title
Increased Cardiac Troponin I Concentration in Diabetic Ketoacidosis.
- Authors
Atabek, Mehmet Emre; Pirgon, Ozgur; Oran, Bülent; Erkul, Ibrahim; Kurtoglu, Selim
- Abstract
Objective: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Methods: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnl), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. Results: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnl (0.193 ± 0.008 vs 0.176 ± 0.006 ng/dl; ? <0.001), CK-MB (24.1 ± 2.1 vs 22.7 ± 1.2 U/l; ? = 0.02), and myoglobin (85.5 ± 7.4 vs 52.5 ± 8.3 µg/dl; ? <0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24 ± 2.1 vs 22.7 ± 1.2 U/l; ? - 0.02) and for myoglobin (78.5 ± 2.5 vs 52.5 ± 8.3 pg/dl; ? <0.001) at 24 h. cTnl had normalized in patients at 24 h. All parameters were significantly different between patients with pH >7.0 and patients with pH <7.0. In addition, serum cTnl levels correlated negatively with blood pH (r = -0.57, ? = 0.026) and HCOj (r = -0.65, ? = 0.008) in the patients with diabetic ketoacidosis on admission. Conclusion: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2004, Vol 17, Issue 8, p1077
- ISSN
0334-018X
- Publication type
Article