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- Title
Modulation of GHRH-Induced Growth Hormone Release by an Alpha-Adrenergic Agonist and Hypoglycemia.
- Authors
Reiter, Edward O.; Morris, Alan H.; Biggs, Darlene E.
- Abstract
Neurohumoral and metabolic regulation of secretion of GH is complex, involving multiple neurotransmitters and peripheral factors. To assess the short term relationship between GHRH-induced GH release and that induced by adrenergic and hypoglycemic stimuli, we administered GHRH (1 jug/kg) prior to and after giving oral Clonidine (150ug/m2) and IV insulin (0.1 μ/kg) to a heterogeneous group of 59 children and adolescents with short stature. All children had normal GH levels following Clonidine or insulin. Peak GH levels (57.3±7.3 ng/ml) evoked by GHRH administered 90 minutes after Clonidine significantly (p<0.0025) exceeded those when GHRH was given initially (25.8±5.6). GHRH-induced GH release 90 minutes after insulin-induced hypoglycemia (39.7±7.8) was similar to the basal GHRH study, but differed from suppressed responses reported in adults given GHRH 120 minutes after insulin. Responses to Clonidine were not altered by prior GHRH. We speculate that the alpha-adrenergic agent, Clonidine, may induce short term suppression of SRIF release, along with increased endogenous GHRH release, leading to increased sensitivity of pituitary somatotropes to exogenous GHRH.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 1988, Vol 3, Issue 1, p21
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.1988.3.1.21