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- Title
Evaluation of Herb-Drug Interactions of Hovenia dulcis Fruit Extracts.
- Authors
Jong Suk Park; Ur Rehman, Shaheed; In Sook Kim; Min Sun Choi; Chun-Soo Na; Hye Hyun Yoo
- Abstract
Background: Hovenia dulcis (Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including H. dulcis fruit extracts, to be taken with prescription drugs. Objective: In this study, possible food-drug interactions involving H. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. Material and Methods: The water extract of H. dulcis fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry. Results: H. dulcis fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested. Conclusion: This result suggests that H. dulcis fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes.
- Subjects
HOVENIA dulcis; FRUIT extracts; DRUG interactions; RHAMNACEAE; EXTRACTS
- Publication
Pharmacognosy Magazine, 2017, Vol 13, Issue 50, p236
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/0973-1296.204552