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- Title
Completing the Picture—Capturing the Resistome in Antibiotic Clinical Trials.
- Authors
Stewart, Adam G; Satlin, Michael J; Schlebusch, Sanmarié; Isler, Burcu; Forde, Brian M; Paterson, David L; Harris, Patrick N A
- Abstract
Despite the accepted dogma that antibiotic use is the largest contributor to antimicrobial resistance (AMR) and human microbiome disruption, our knowledge of specific antibiotic-microbiome effects remains basic. Detection of associations between new or old antimicrobials and specific AMR burden is patchy and heterogeneous. Various microbiome analysis tools are available to determine antibiotic effects on microbial communities in vivo. Microbiome analysis of treatment groups in antibiotic clinical trials, powered to measure clinically meaningful endpoints would greatly assist the antibiotic development pipeline and clinician antibiotic decision making.
- Subjects
ANTIBIOTICS; CLINICAL trials; HUMAN microbiota; DRUG resistance in microorganisms
- Publication
Clinical Infectious Diseases, 2021, Vol 72, Issue 12, pe1122
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciaa1877