We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synergistic Effects of Methotrexate and Suberoylanilide Hydroxamic Acid in Triggering Apoptosis of Chronic Myeloid Leukemia Cells.
- Authors
ALTUNDAG, Ergul M.; YILMAZ, Ayse M.; COREK, Ceyda; YALCIN, A. Suha; TAGA, Yavuz; KOCTURK, Semra
- Abstract
In this study, we have investigated the effects of suberoylanilide hydroxamic acid (SAHA) against chronic myeloid leukemia (CML) cells in combination studies with methotrexate (MTX), which is a dihydrofolate reductase inhibitor used in combination therapy with other agents or alone. Combination of synergistic ratios of MTX and SAHA led to apoptotic cell death of CML cells via PARP cleavage, cytochrome c release and ROS increase in vitro. We suggest that combination of MTX and SAHA may minimize the toxicity and side effects of SAHA treatment, thus providing lower amounts of each drug in CML treatment.
- Subjects
HYDROXAMIC acids; TREATMENT of chronic myeloid leukemia; METHOTREXATE; TOXICITY testing; CELL death
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2015, Vol 25, Issue 1, p1
- ISSN
1306-133X
- Publication type
Article
- DOI
10.4999/uhod.15634