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- Title
Multiple painful leiomyomas of the skin: a novel therapy with sympathicolysis?
- Authors
Hauschild, Axel; Maier, Christoph; Christophers, Enno
- Abstract
Leiomyomatosis cutis is a rare disease involving large areas of the body surface with painful leiomyomas. Only a small panel of drugs has provided limited effects in the management of paroxysmal pain attacks associated with these tumours. Two patients with multiple. otherwise therapy-refractory cutaneous leiomyomas predominantly on the extremities underwent experimental transient sympathicolysis. Experimental cold exposure and noradrenalin injections resulted in increasing pain and vasoconstriction, whereas sympathicolysis counteracted this with pain reduction and vasodilatation. Our results confirm that α-adrenergic fibres play an important role in smooth muscle contraction and pain induction in cutaneous leiomyomas. Sympathicolysis should be induced in the therapeutic choices available for multiple painful leiomyomas localized on the extremities.
- Subjects
SMOOTH muscle tumors; NEUROBLASTOMA; TUMORS in children; SARCOMA; TACHYCARDIA; DERMATOLOGY
- Publication
Journal of the European Academy of Dermatology & Venereology, 1997, Vol 9, Issue 3, p262
- ISSN
0926-9959
- Publication type
Report
- DOI
10.1111/j.1468-3083.1997.tb00515.x