We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization
- Authors
Cheung, Derek Hang-Cheong; Kung, Hsiang-Fu; Huang, Jun-Jian; Shaw, Pang-Chui
- Abstract
Abstract: Telomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells.
- Subjects
TELOMERASE; GENETICS; CELL cycle; CHROMOSOMES; ANAPHASE; GENE silencing
- Publication
FEBS Letters, 2012, Vol 586, Issue 19, p3166
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.06.028