We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recognition of the ligand-type specificity of classical and non-classical MHC I proteins
- Authors
Martínez-Naves, Eduardo; Lafuente, Esther M.; Reche, Pedro A.
- Abstract
Abstract: Functional characterization of proteins belonging to the MHC I superfamily involves knowing their cognate ligands, which can be peptides, lipids or none. However, the experimental identification of these ligands is not an easy task and generally requires some a priori knowledge of their chemical nature (ligand-type specificity). Here, we trained k-nearest neighbor and support vector machine classifiers that predict the ligand-type specificity MHC I proteins with great accuracy. Moreover, we applied these classifiers to human and mouse MHC I proteins of uncharacterized ligands, obtaining some results that can be instrumental to unravel the function of these proteins.
- Subjects
MAJOR histocompatibility complex; LIGANDS (Biochemistry); PEPTIDES; LIPIDS; SUPPORT vector machines; PROTEINS
- Publication
FEBS Letters, 2011, Vol 585, Issue 21, p3478
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.10.007