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- Title
Hsa-miR-30e-3p inhibits influenza B virus replication by targeting viral NA and NP genes.
- Authors
Khongnomnan, Kritsada; Saengchoowong, Suthat; Mayuramart, Oraphan; Nimsamer, Pattaraporn; Pisitkun, Trairak; Poovorawan, Yong; Payungporn, Sunchai
- Abstract
Influenza B virus is a member of the Orthomyxoviridae family which can infect humans and causes influenza. Although it is not pandemic like influenza A virus, it nevertheless affects millions of people worldwide annually. MicroRNAs are small non-coding RNAs regulating gene expression at posttranscriptional level. They play various important roles in cellular processes including response to viral infection. MiRNA profiles from our previous study suggested that miR-30e-3p was one of the upregulated miRNAs that responded to influenza B virus infection. In this study, in silico prediction and in vitro investigation proved that this miRNA can directly target NA and NP genes of the influenza B virus and inhibit its replication. This finding might be useful for using miRNA as an alternative therapeutics for influenza virus infection.
- Publication
Experimental Biology & Medicine, 2020, Vol 245, Issue 18, p1664
- ISSN
1535-3702
- Publication type
Article
- DOI
10.1177/1535370220953151