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- Title
Rose (Rosa rugosa)-flower extract increases the activities of antioxidant enzymes and their gene expression and reduces lipid peroxidation.
- Authors
Ng, T. B.; Gao, W.; Li, L.; Niu, S. M.; Zhao, L.; Liu, J.; Shi, L. S.; Fu, M.; Liu, F.
- Abstract
The effects of rose-flower extract on antioxidant enzymes were studied. The activities of catalase (CAT) and glutathione peroxidase (GPx) in 9-month-old senescence-accelerated mice (SAM mice) were lower than those in 6-month-old SAM mice. Therefore, 9-month-old SAM mice were the most appropriate targets for treatment with the rose-flower extract. The activities of CAT and GPx in SAM mice treated with rose-flower extract showed a marked increase in whole blood and liver. At the same time, the gene-expression level of CAT and GPx was upregulated in the liver, while malondialdehyde content in liver and brain decreased. Male SAM mice were more sensitive than female SAM mice. The mean and the longest lifespan of SAM mice were longer after treatment with rose-flower extract.Key word: anti-aging, CAT, GPx, lipid peroxidation.
- Subjects
ROSES; RUGOSA rose; ENZYMES; GENE expression; PEROXIDATION; LIPIDS
- Publication
Biochemistry & Cell Biology, 2005, Vol 83, Issue 1, p78
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/O04-100