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- Title
Putting immunoinformatics to the test.
- Authors
Moise, Leonard; De Groot, Anne S.
- Abstract
The article discusses the use of epitope-mapping tools in the discovery of viral sequences that account the T-cell response to vaccinia virus in a mouse model. An epitope is a biological sequence like protein and carbohydrate recognized by an antibody as an antigen. In a recent study, vaccinia T-cell epitopes had been predicted through the application of cytokine and cell-marker measurement techniques. In addition, the tools suggest application in humans and on transplantation priming effects.
- Subjects
EPITOPES; IMMUNE recognition; VACCINIA; VIRAL antibodies; TRANSPLANTATION immunology
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 7, p791
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0706-791