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- Title
Sialylated endogenous glycoconjugates in plant cells.
- Authors
Fujiyama, Kazuhito; Joshi, Lokesh; Shah, Miti M.; Flynn, C. Robert
- Abstract
Bioengineered plants are emerging as promising systems for the production of therapeutically valuable proteins. It has been commonly accepted that plants do not perform mammalian-like post-translational modifications, particularly sialylation of glycoconjugates, and no evidence has previously been reported to suggest that they have such capabilities. Here we report the presence of sialylated glycoconjugates in suspension-cultured cells of Arabidopsis thaliana and suggest that a genetic and enzymatic basis for sialylation exists in plants.
- Subjects
AGRICULTURAL engineering; BIOENGINEERING; PLANT cells &; tissues; THERAPEUTIC use of proteins; GLYCOCONJUGATES; ARABIDOPSIS thaliana
- Publication
Nature Biotechnology, 2003, Vol 21, Issue 12, p1470
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt912