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- Title
Recombinant maxi-K channels on transistor, a prototype of iono-electronic interfacing.
- Authors
Straub, Bernhard; Meyer, Elisabeth; Fromherz, Peter
- Abstract
We report on the direct electrical interfacing of a recombinant ion channel to a field-effect transistor on a silicon chip. The ion current through activated maxi-K[SUBCa] channels in human embryonic kidney (HEK293) cells gives rise to an extracellular voltage between cell and chip that controls the electronic source-drain current. A comparison with patch-clamp recording shows that the channels at the cell/chip interface are fully functional and that they are significantly accumulated there. The direct coupling of potassium channels to a semiconductor on the level of an individual cell is the prototype for an iono-electronic interface of ligand-gated or G protein-coupled ion channels and the development of screening biosensors with many transfected cells on a chip with a large array of transistors.
- Subjects
ION channels; TRANSISTORS; BIOELECTRONICS
- Publication
Nature Biotechnology, 2001, Vol 19, Issue 2, p121
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/84369