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- Title
Management of postradiation late hemorrhage following treatment for HPV‐positive oropharyngeal squamous cell carcinoma.
- Authors
Stevens, Madelyn N.; Gallant, Jean‐Nicolas; Feldman, Michael J.; Sermarini, Anthony J.; Cmelak, Anthony; Murphy, Barbara; Langerman, Alexander; Kim, Young; Rohde, Sarah L.; Mannion, Kyle; Sinard, Robert J.; Netterville, James L.; Chitale, Rohan; Topf, Michael C.
- Abstract
Background: Acute oropharyngeal hemorrhage is a serious complication for patients with oropharyngeal squamous cell carcinoma (OPSCC), particularly in patients with a history of radiation therapy (RT). Methods: Retrospective case series from at a tertiary care center for treated patients with HPV‐positive OPSCC presenting with oropharyngeal hemorrhage. Results: Median time from completion of chemoradiation to first hemorrhagic event was 186 days (range 66–1466 days). Seven patients (58%) required intervention to secure their airway. All patients were evaluated for endovascular intervention, six (50%) were embolized. Eight patients (67%) had a second hemorrhagic event; median time to second bleed was 22 days (range 3–90 days). Conclusions: Acute oropharyngeal hemorrhage is a sequelae following treatment for HPV‐positive OPSCC. The majority of bleeds occurred within a year of completion of treatment. While more research is needed to determine optimal treatment paradigms, endovascular intervention should be considered, even if noninvasive imaging does not demonstrate active bleeding.
- Subjects
SQUAMOUS cell carcinoma; ENDOVASCULAR surgery; HEMORRHAGE
- Publication
Head & Neck, 2022, Vol 44, Issue 5, p1079
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27001