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- Title
Candidate Gene Analysis of Femoral Neck Trabecular and Cortical Volumetric Bone Mineral Density in Older Men.
- Authors
Yerges, Laura M.; Klei, Lambertus; Cauley, Jane A.; Roeder, Kathryn; Kammerer, Candace M.; Ensrud, Kristine E.; Nestlerode, Cara S.; Lewis, Cora; Lang, Thomas F.; Barrett-Connor, Elizabeth; Moffett, Susan P.; Hoffman, Andrew R.; Ferrell, Robert E.; Orwoll, Eric S.; Zmuda, Joseph M.
- Abstract
The article discusses the different genetic variants related to trabecular and cortical related to volumetric bone mineral density (vBMD). The study was participated by 822 Caucasian men aged 65 years-old and above from the Osteoporotic Fractures in Men Study (MrOS). Single-nucleotide polymorphisms were seen in five genes, which in turn is associated with cortical vBMD and SNP that are largely related to trabecular vBMD. The study concluded that some genetic loci can be a good bone compartment due to the genetic variants of cortical and trabecular vBMD.
- Subjects
GENES; FEMUR neck; BONE density; OLDER men; CAUCASIAN race
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 2, p330
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/jbmr.090729