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- Title
Coagulation effects of a recently developed hydroxyethyl starch (HES 130/0.4) compared to hydroxyethyl starches with higher molecular weight.
- Authors
Entholzner, E. K.; Mielke, L. L.; Calatzis, A. N.; Feyh, J.; Hipp, R.; Hargasser, S. R.
- Abstract
<bold>Background: </bold>Hydroxyethyl starches (HES) are known to interfere with blood coagulation according to molecular weight, the degree of substitution and the C2/C6 ratio. A recently developed low molecular hydroxyethyl starch (HES 130/0.4) was designed to reduce the blood compromising potency.<bold>Methods: </bold>In this study, effects of a 30% in vitro haemodilution with the new HES preparation (HES 130/0.4) in comparison to HES 200/0.5, HES 450/0.7 and sodium chloride solution were investigated using intrinsic and extrinsic activated thrombelastography (TEG) and plasmatic coagulation tests.<bold>Results: </bold>Whereas plasmatic tests revealed no prolongation of coagulation by HES in comparison to sodium chloride, the TEG variables clotting time, clot formation time and maximal clot firmness showed a significant (P<0.05) inhibition by all the HES preparations. The inhibition was most pronounced in HES 450 (P<0.05 vs HES 130) while HES 130 did not show a statistically significant difference in extrinsic activated maximal clot firmness when compared to sodium chloride.<bold>Conclusion: </bold>These in vitro results demonstrate that hydroxythyl starches especially compromise clot polymerisation. The new preparation HES 130/0.4 seems to inhibit platelet function to a lesser extent than hydroxyethyl starch preparations with a higher molecular weight and degree of substitution.
- Subjects
BLOOD coagulation; HYDROXYETHYL starch; MOLECULAR weights; ANTICOAGULANTS; BLOOD coagulation tests; BLOOD plasma substitutes; PHYSICAL &; theoretical chemistry; COMPARATIVE studies; HEMODILUTION; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SALT; THROMBELASTOGRAPHY; EVALUATION research; PARTIAL thromboplastin time; PROTHROMBIN time; IN vitro studies; PHARMACODYNAMICS
- Publication
Acta Anaesthesiologica Scandinavica, 2000, Vol 44, Issue 9, p1116
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1034/j.1399-6576.2000.440914.x