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- Title
Relationship between Characteristics of Genetic Study and Essential Thrombocythemia in Aged Patients.
- Authors
Toshihide Harada; Fumiko Ishizaki; Yumiko Miki; Yumiko Nitta; Miwa Hayama; Jyunnya Aonaka; Yuko Kodama; Shoji Ito; Ryuta Yamamoto; Katsuyuki Niyada; Hiroyuki Miyazaki; Satomi Aoi; Hiromi Ikeda; Tadayuki Iida; Hanayo Hiroto; Juko Ando; Kohsaku Nitta
- Abstract
Objective: Essential thrombocythaemia is a rare disease. Design: A clinical study. Materials and Methods: An 86-year-old man had marked thrombocytosis, increased leukocyte count and anemia. Analysis of the Janus Activating Kinase 2 (JAK2) V617F (GTC→TTC) gene from his leukocytes demonstrated the JAK2 mutation (V617F GTC→TTC, G1849T, exon 14). Results: A diagnosis of essential Thrombocythaemia was made. Conclusions: He has been good in health without chemotherapy since then.
- Subjects
ANEMIA; GENETICS; GENETIC mutation; THROMBOCYTOSIS; PROTEIN kinase inhibitors; LEUKOCYTE count; OLD age
- Publication
International Medical Journal, 2019, Vol 26, Issue 5, p438
- ISSN
1341-2051
- Publication type
Article