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- Title
Development and Pilot of an Mpox Severity Scoring System.
- Authors
Zucker, Jason; McLean, Jacob; Huang, Simian; DeLaurentis, Clare; Gunaratne, Shauna; Stoeckle, Kate; Glesby, Marshall J; Wilkin, Timothy J; Fischer, William; Damon, Inger; Brooks, John T
- Abstract
Clinical severity scores facilitate comparisons to understand risk factors for severe illness. For the 2022 multinational monkeypox clade IIb virus outbreak, we developed a 7-item Mpox Severity Scoring System (MPOX-SSS) with initial variables refined by data availability and parameter correlation. Application of MPOX-SSS to the first 200 patients diagnosed with mpox revealed higher scores in those treated with tecovirimat, presenting >3 days after symptom onset, and with CD4 counts <200 cells/mm3. For individuals evaluated repeatedly, serial scores were concordant with clinical observations. The pilot MPOX-SSS demonstrated good discrimination, distinguished change over time, and identified higher scores in expected groups.
- Subjects
MONKEYPOX; CD4 lymphocyte count; COMMUNICABLE diseases
- Publication
Journal of Infectious Diseases, 2024, Vol 229, pS229
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad492