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- Title
Expression of Surfactant Protein D Distinguishes Severe Pandemic Influenza A(H1N1) from Coronavirus Disease 2019.
- Authors
Choreño-Parra, José Alberto; Jiménez-Álvarez, Luis Armando; Ramírez-Martínez, Gustavo; Cruz-Lagunas, Alfredo; Thapa, Mahima; Fernández-López, Luis Alejandro; Carnalla-Cortés, Martha; Choreño-Parra, Eduardo M; Mena-Hernández, Lourdes; Sandoval-Vega, Montserrat; Hernández-Montiel, Erika Mariana; Hernández-García, Diana Lizzeth; Ramírez-Noyola, Jazmín Ariadna; Reyes-López, Cynthia Estefania; Domínguez-Faure, Andrea; Zamudio-López, Guillermo Yamil; Márquez-García, Eduardo; Moncada-Morales, Angélica; Mendoza-Milla, Criselda; Cervántes-Rosete, Diana
- Abstract
The differentiation between influenza and coronavirus disease 2019 (COVID-19) could constitute a diagnostic challenge during the ongoing winter owing to their clinical similitude. Thus, novel biomarkers are required to enable making this distinction. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in patients with severe pandemic influenza but not those with COVID-19. This finding was validated in a separate cohort of mechanically ventilated patients with COVID-19 who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with death and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.
- Subjects
INFLUENZA; PULMONARY surfactant-associated protein D; COVID-19; PANDEMICS; PROTEIN expression; SEASONAL influenza
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 1, p21
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab113