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- Title
Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors.
- Authors
Zheng, Ming; Zheng, Youguang; Xue, Yunsheng; Liu, Yi; An, Lin; Zhang, Ling; Ji, Min; Xue, Bai; Wu, Xuan; Gong, Xuedong; Gu, Ning; Zhan, Xi
- Abstract
Nine novel 4-aminoquinazoline derivatives were designed and synthesized. Biochemical and cellular analyses demonstrated that most of the derivatives exhibited a strong activity to inhibit Aurora A and B kinases and to suppress the proliferation of a panel of human tumor cell lines (U937, K562, A549, LoVo, and HT29). Quantum chemical studies were also carried out to determine the structural features of these compounds engaged in the inhibition of Aurora kinases.
- Subjects
QUANTUM chemistry; QUINAZOLINE; CHEMICAL derivatives; KINASE inhibitors; CANCER cells; CELL proliferation; AURORA kinases
- Publication
Chemical Biology & Drug Design, 2013, Vol 81, Issue 3, p399
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12089