We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma.
- Authors
He, Andong; Chen, Jiaqian; Guan, Jieying; Huang, Yuye; Xie, Huancheng; Chen, Honglv; Wen, Yuhuan; Chen, Qile; Xie, Shiyun; Li, Haoyang; Ou, Changxing; Zhang, Qingling; Tao, Ailin; Yan, Jie
- Abstract
To investigate the role of eosinophil necroptosis in asthma, we adoptively transferred eosinophils to the airways of OVA/CFA-induced mice (Figure S2A). Abbreviation BALF Bronchoalveolar Lavage Fluid CFA Complete Freund's adjuvant DAMPs damage-associated molecular patterns EMBP Eosinophil Major Basic Protein MFI mean fluorescence intensity MLKL Mixed Lineage Kinase Domain Like Pseudokinase OVA Ovalbumin RIPK1 Receptor-interacting protein kinase 1 Asthma is a widespread inflammatory disease characterized by airway inflammation, remodeling, and hyperresponsiveness (AHR),1,2 that eosinophils are assumed to play essential roles in the development of asthma and are associated with asthma severity.3,4 Recently, accumulating evidence demonstrates that programmed cell death plays critical roles in eosinophil degranulation and pathological processes.
- Subjects
EOSINOPHILS; ASTHMA; MEDICAL ethics; CYTOLOGY; PATHOLOGICAL physiology; PULMONARY eosinophilia; NECROSIS
- Publication
Allergy, 2022, Vol 77, Issue 11, p3456
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15448