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- Title
Effect of chronic β-blockade on peri-operative outcome in patients undergoing non-cardiac surgery: an analysis of observational and case control studies*.
- Authors
Giles, J. W.; Sear, J. W.; Foëx, P.
- Abstract
Little is known about the effect of chronic β-adrenoceptor antagonist therapy during the peri-operative period in patients undergoing non-cardiac surgery. We conducted a literature review to identify studies examining the relationship between chronic therapy and adverse peri-operative outcome. Eighteen studies were identified in which it was possible to ascertain the incidence of adverse cardiac outcomes in those patients who were and were not receiving chronic β-blocker therapy. None of the studies demonstrated a protective effect of chronic β-blockade. The results of these studies were then combined and a cumulative odds ratio calculated for the likelihood of myocardial infarction, cardiac death and major cardiac complications. Patients receiving chronic β-blocker therapy were more likely to suffer a myocardial infarction (p < 0.05). These findings differ from the published effects of acute β-blockade. Reasons for this discrepancy are considered.
- Subjects
ADRENERGIC receptors; HEALTH outcome assessment; SURGICAL complications; LITERATURE reviews; MYOCARDIAL infarction; HEART diseases
- Publication
Anaesthesia, 2004, Vol 59, Issue 6, p574
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2004.03706.x