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- Title
Use of the MDRD Study Equation to Estimate Kidney Function for Drug Dosing.
- Authors
Stevens, L. A.; Levey, A. S.
- Abstract
In this article the authors assert on the use of appropriate method for evaluating kidney function in determining drug dosage. It asserts on the inappropriateness of the Modification of Diet in Renal Disease (MDRD) study and Cockcroft-Gaul (C-G) equations in translating pharmacokinetic (PK) studies to clinical practice. It implies on using creatinine assays and kidney-function testing to ascertain drug dosage and to estimate care for patients with acute and chronic kidney disease.
- Subjects
KIDNEY disease diagnosis; DRUG dosage; KIDNEY function tests; CREATININE; PHARMACEUTICAL arithmetic; CHRONIC kidney failure; PHARMACOKINETICS; PATIENTS
- Publication
Clinical Pharmacology & Therapeutics, 2009, Vol 86, Issue 5, p465
- ISSN
0009-9236
- Publication type
Opinion
- DOI
10.1038/clpt.2009.124